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Clinically Supporting Mood, Self-Esteem, and Sleep-Related Outcomes in Menopausal Women

Access the full clinical publication and explore how 28 mg/day of Affron® improved mood and self-esteem, and reduced sleep impairment in women aged 50–70 years.

 Randomized, double-blind, placebo-controlled clinical study — published in Frontiers in Nutrition. 

Why this study matters?

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A common health challenge in women aged 50–70

Women during and after the menopausal transition are particularly vulnerable to low mood, poor sleep, and reduced self-esteem.

This clinical study evaluated the effects of Affron®, a standardized saffron extract, in women aged 50–70 years experiencing low mood and sleep disturbances.

The study assessed:

  • Low mood symptoms
  • Sleep impairment outcomes
  • Self-esteem
  • and more.

Key Study Results

Untitled design (14)

 Self-Esteem Improvement

vs. +4.8% placebo
Moderate effect size (d = 0.51)
Rosenberg Scale (p = 0.022)
1

Clinical Improvement in Low Mood

vs. 25.6% with placebo (p=0.026)

2

 Reduction in DASS-D Score

vs. 31.9% with placebo

Why this is important

Affron® demonstrated significant improvements in low mood (DASS-D), self-esteem (RSE), and sleep-related impairment, highlighting its ability to support multiple interconnected dimensions of emotional wellbeing.

Scientific Conclusion

“Supplementation with Affron during 12 weeks was associated with improvements in low mood symptoms, self-esteem, and sleep impairment in women aged 50 to 70 years.”
 
— Lopresti & Smith, Frontiers in Nutrition, 2026

Download the Full Clinical Study 

Access the complete Frontiers in Nutrition publication, including study design, methodology, results, and scientific conclusions.